PReS-FINAL-1009: Antioxidant superoxide dismutase activity is paradoxically normal in juvenile systemic lupus erythematosus
نویسندگان
چکیده
Introduction Damage via generation of free radicals has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Numerous studies demonstrate both direct and surrogate evidence for a high burden of oxidative and nitrative stress which parallels disease activity. Antioxidants such as superoxide dismutase (SOD) function to protect against oxidative damage by neutralizing free radicals and levels are typically elevated in situations of high oxidative stress.
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